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J Michael Bradshaw Selected Research

PRN1371

12/2017The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance.
10/2017Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

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J Michael Bradshaw Research Topics

Disease

2Skin Diseases (Skin Disease)
01/2021 - 01/2018
2Arthus Reaction
01/2021 - 01/2021
2Colitis
12/2018 - 11/2015
2Neoplasms (Cancer)
12/2017 - 10/2017
1Experimental Arthritis
01/2021
1Nephritis
01/2021
1Pemphigus (Pemphigus Vulgaris)
01/2021
1Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
01/2021
1Autoimmune Diseases (Autoimmune Disease)
12/2018
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
12/2018
1Psoriasis (Pustulosis Palmaris et Plantaris)
01/2018
1Disease Progression
11/2015
1T-Cell Prolymphocytic Leukemia (Leukemia, T Cell, Chronic)
03/2015
1Hypersensitivity (Allergy)
03/2015
1Lymphoma (Lymphomas)
02/2011

Drug/Important Bio-Agent (IBA)

2Agammaglobulinaemia Tyrosine KinaseIBA
01/2021 - 02/2011
2PRN694IBA
01/2018 - 11/2015
2Pharmaceutical PreparationsIBA
12/2017 - 02/2011
2PRN1371IBA
12/2017 - 10/2017
1Immunoglobulin G (IgG)IBA
01/2021
1PRN473IBA
01/2021
1AutoantibodiesIBA
01/2021
1Interleukin-6 (Interleukin 6)IBA
12/2018
1PR-957IBA
12/2018
1Imiquimod (Aldara)FDA LinkGeneric
01/2018
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
12/2017
1Phosphotransferases (Kinase)IBA
12/2017
1OxazoloneIBA
03/2015